Cyanuric chloride → HCID 57396254, compound

Participants

Reaction Steps

A solution 2-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-indole-4-carboxylic acid amide (95 mg, 0.21 mmol) in 1 mL of DMF was reacted with cyanuric chloride (46 mg, 0.25 mmol). After 3 hours, the mixture was treated with sodium bicarbonate, extracted with dichloromethane. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give 33 mg of the title product as off-white solid (36% yield).

Provenance & Evidence