Hydrochloric Acid → HCID 50943809, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 4-(2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-3-(4-fluorophenyl)butanoate (100 mg, 0.24 mmol) was dissolved in 10 mL of MeOH. To this solution was added 1N NaOH (5 mL). The reaction mixture was heated in an oil bath at a temperature of 50° C. overnight. The reaction mixture was cooled to RT, acidified with 1M HCl and evaporated to dryness. The residue was purified by HPLC to obtain 50 mg of product as the TFA salt.

Provenance & Evidence