Methyl iodide → HCID 58064854, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 75 mg of 1-bromo-2,3-dihydroxy-5-nitronaphthalene in 3.0 ml of DMF was added K2CO3 and Methyl iodide. The resulting solution was heated at 50° C. overnight after which the reaction mixture was diluted with water and extracted with ethyl acetate. Column chromatography using 30% ethyl acetate in hexane afforded the product, 1-bromo-5-nitro-2,3-dimethoxynaphthalene as a yellow solid. (Yield: 60 mg; 1H NMR (CDCl3) δ 3.99 (s, 3H), 4.04 (s, 3H), 7.45-7.53 (m, 1H), 7.98 (s, 1H), 8.21 (dd, J=6.0 Hz, 1.2 Hz, 1H), 8.51 (dd, J=6.0 Hz, 1.2 Hz, 1H).

Provenance & Evidence