Methyl iodide → HCID 58064922, compound

Participants

Reaction Steps

To a suspension of benzamide N-(4-(biphenyl-4-yl)-6,7-dimethoxynaphthalen-1-yl)5-bromobenzo[1,3]dioxole-4-carboxamide (1 mmol), and NaH (3 mmol) in dry DMF (20 mL) was added MeI (2 equiv). The reaction mixture was stirred over night, diluted with ether and then washed with 10% HCl and brine. The residue was subjected to column chromatography on silica using 2% methanol in chloroform to provide product N-(4-(biphenyl-4-yl)-6,7-dimethoxynaphthalen-1-yl)5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide as an off white solid. 1H NMR (400 MHz) (CDCl3) δ 3.39-3.60 (m, 3H, N—CH3), 3.66-3.80 (m, 3H, O—CH3), 3.96-4.00 (m, 3H, O—CH3), 5.03-6.18 (m, 2H, O—CH2O), 6.30-7.69 (m, 15H, aromatic).

Provenance & Evidence