Hydrochloric Acid → 4-[(2R)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

4-[(2R)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzonitrile (1.40 g; 5.22 mmol; 1 eq.) was dissolved in MeOH (7 mL) to which was added NaOH (5 N solution in water, 7 mL). The reaction mixture was heated to 100° C. for 7 hours. The reaction mixture was acidified to pH 2 with 5N HCl solution in water. The resulting precipitate was filtered and washed with water to give a light brown solid. It was recrystallized from Et2O/cHex to give a beige solid.

Provenance & Evidence