4-[(2S)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzoic acid → HCID 178461177, compound

HRID 400780Notes

Reaction equation

HRID 400780 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][C:9]=1[C:17]([F:20])([F:19])[F:18].O[N:22]=[C:23]([C:25]1[CH:33]=[CH:32][C:28]2[NH:29][CH:30]=[N:31][C:27]=2[CH:26]=1)[NH2:24]>>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]2[O:14][N:22]=[C:23]([C:25]3[CH:33]=[CH:32][C:28]4[NH:29][CH:30]=[N:31][C:27]=4[CH:26]=3)[N:24]=2)=[CH:10][C:9]=1[C:17]([F:19])([F:18])[F:20]

Participants

3

Reactant 2

HCID 580662204-[(2S)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzoic acidHCID 178513241N'-hydroxy-3H-benzimidazole-5-carboximidamide

Product 1

HCID 178461177HCID 178461177, compound

Procedure

Title compound was prepared following general procedure 3 starting from Intermediate 27 (300 mg; 1.04 mmol; 1 eq.), and Intermediate 1 (183.98 mg; 1.04 mmol; 1 eq.). After evaporation of the solvents, the solid residue was triturated with ACN, filtered and dried under vacuum to give the title compound as an off-white solid. 1H NMR (DMSO-d5) δ 12.78 (br m, 1H), 8.50-8.26 (m, 2H), 8.04-7.68 (m, 3H), 3.16 (m, 1H), 3.02-2.90 (m, 1H), 2.69-2.55 (m, 1H), 1.87-1.20 (m, 6H), 0.78 (d, J=6.1 Hz, 3H). HPLC (Method A), Rt 5.04 min (Purity: 98.4%). LC/MS (Method B): 426.3 (M+H)−; 428.1 (M+1-1)+.

Workup

  1. customTitle compound was prepared
  2. customAfter evaporation of the solvents
  3. customthe solid residue was triturated with ACN
  4. filtrationfiltered
  5. customdried under vacuum

Sources & evidence

ORD record
ord-2afa6e6c93cb4627bcc01c5c92dbe100
Source dataset
uspto-grants-2014_06
Patent number
US08741923B2

Reaction notes

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