tert-butyl [7-[amino(hydroxyimino)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]acetate → tert-butyl [7-{5-[4-(2-ethylpiperidin-1-yl)-3-(methoxymethyl)phenyl]-1,2,4-oxadiazol-3-yl}-3,4-dihydroisoquinolin-2(1H)-yl]acetate

Participants

Role	Name	HCID	Charge
Reactant	tert-butyl [7-[amino(hydroxyimino)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]acetate	HCID 76787421	—
Reactant	4-(2-Ethylpiperidin-1-yl)-3-(methoxymethyl)benzoic acid hydrochloride	HCID 131731430	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	tert-butyl [7-{5-[4-(2-ethylpiperidin-1-yl)-3-(methoxymethyl)phenyl]-1,2,4-oxadiazol-3-yl}-3,4-dihydroisoquinolin-2(1H)-yl]acetate	HCID 68653561	—

Reaction Steps

Title compound was prepared following general procedure 2 starting from Intermediate 22 (188 mg; 0.6 mmol) and Intermediate 5 (174 mg; 0.6 mmol). The reaction mixture was diluted with EtOAc, washed with water and brine and evaporated under vacuum.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08741923B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-89ddd36e512946a7812b9b8f2d18a2b8
Source note	uspto-grants-2014_06