2'-Methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → tert-butyl [7-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}-3,4-dihydroisoquinolin-2(1H)-yl]acetate

Participants

Reaction Steps

Title compound was prepared following general procedure 2 starting from Intermediate 24 (168 mg; 0.6 mmol) and Intermediate 5 (174 mg; 0.6 mmol). The reaction mixture was diluted with EtOAc, washed with water and brine and evaporated under vacuum. Purification with MD-Autoprep afforded the title compound as a yellow oil. LC/MS (method B): 550.1 (M+H)+. HPLC (Method A) Rt 4.95 min.

Provenance & Evidence