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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 400855Erstellt: 25. Oktober 2026

Cyclohexane, (bromomethyl)- → 5-tert-Butyl-3-cyclohexylmethyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

https://huagongshe.com/reaction/400855

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktCyclohexane, (bromomethyl)-HCID 137636—
Edukt5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 71558205—
EduktHCID 178441789HCID 178441789—
Produkt5-tert-Butyl-3-cyclohexylmethyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 86683303—

Reaktionsschritte

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and (bromomethyl)cyclohexane and isolated as white solid (4.2 mg, 27%). MS (m/e): 379.5 (MH+).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08741906B2
Quelldatensatzuspto-grants-2014_06
ORD IDord-2e783c8b5f2d4a7d95147a423ed06285
Quellennotizuspto-grants-2014_06