化工社化工社 化学情報印刷レポート · 研究参考用
1-(Bromomethyl)-3-chlorobenzene → 5-tert-Butyl-3-(3-chloro-benzyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
| 反応物 | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558205 | — |
| 反応物 | HCID 178441789 | HCID 178441789 | — |
| 生成物 | 5-tert-Butyl-3-(3-chloro-benzyl)-7-(3,3-difluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558206 | — |
反応手順
In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 1-(bromomethyl)-3-chlorobenzene and isolated as light-yellow gum (7.0 mg, 42%). MS (m/e): 407.4 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741906B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-d12dfb59d9ca45d8b019077dadf5e573 |
| 出典メモ | uspto-grants-2014_06 |