5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → HCID 86683307, compound

HRID 400885Notes

Reaction equation

HRID 400885 reaction equation
C(C1N=C(N2CCOCC2)C2N=NN(CC3C=CC=CC=3Cl)C=2N=1)(C)(C)C.[C:28]([C:32]1[N:33]=[C:34](Cl)[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29].Cl.[F:51][C:52]1([F:59])[CH2:56][NH:55][C@@H:54]([CH2:57][OH:58])[CH2:53]1>>[C:28]([C:32]1[N:33]=[C:34]([N:55]2[CH2:56][C:52]([F:59])([F:51])[CH2:53][C@@H:54]2[CH2:57][OH:58])[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29]

Participants

4

Reactant 3

HCID 14339535-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 72207690[(2R)-4,4-difluoropyrrolidin-2-yl]methanol hydrochlorideHCID 866832845-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Product 1

HCID 86683307HCID 86683307, compound

Procedure

In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chlorobenzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and (R)-(4,4-difluoropyrrolidin-2-yl)methanol hydrochloride and isolated as white solid. MS (m/e): 437.3 (MH+).

Workup

  1. customisolated as white solid

Sources & evidence

ORD record
ord-55ed981b09a94a94b7cc225dd1ddda3c
Source dataset
uspto-grants-2014_06
Patent number
US08741906B2

Reaction notes

Loading…