反应详情

Following General Procedure H, (S)-6-(4-(benzyloxymethyl)-4,5-dihydrooxazol-2-yl)-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide was prepared (10 mg, 0.015 mmol), was then reacted with BBr3 (1M in CH2Cl2, 0.05 ml, 0.05 mmol) in CH2Cl2 (2 ml) at −78° C. for 1 h, quenched with water, diluted with EtOAc, washed organic with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography on silica gel (5:95 MeOH—CH2Cl2) to yield the title compound as a white solid.

1. customwas prepared (10 mg, 0.015 mmol)
2. customquenched with water
3. additiondiluted with EtOAc
4. washwashed organic with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. customThe residue was purified by chromatography on silica gel (5:95 MeOH—CH2Cl2)