5-(chloromethyl)-1,3-dimethyl-1H-1,2,4-triazole → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(2,5-dimethyl-2H-[1,2,4]triazol-3-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

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Reaction Steps

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo [4,5-d]pyrimidine and 5-(chloromethyl)-1,3-dimethyl-1H-1,2,4-triazole and isolated as light-yellow gum. MS (m/e): 392.3 (MH+).

Provenance & Evidence