HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-2-methanesulfonylbenzene → 5-tert-Butyl-3-(2-methanesulfonyl-benzyl)-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-2-methanesulfonylbenzene | HCID 18922474 | — |
| Reactant | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558205 | — |
| Reactant | HCID 178441781 | HCID 178441781 | — |
| Product | 5-tert-Butyl-3-(2-methanesulfonyl-benzyl)-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 86683363 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-Butyl-7-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 1-(bromomethyl)-2-(methylsulfonyl)benzene and isolated as white solid. MS (m/e): 443.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741906B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-0b79e36e65474ccead7d6132e0f1aff0 |
| Source note | uspto-grants-2014_06 |