Ethyl orthoformate → HCID 59762338、化合物

HRID 40096ノート

反応式

HRID 40096 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]([NH:19][NH2:20])=[O:18])[CH:15]=2)[C:10]([C:21]([NH:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[C:27]([F:32])[CH:26]=2)=[O:22])=[C:9]1[CH:33]([CH3:35])[CH3:34])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:36](OCC)(OCC)OCC>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]3[O:18][CH:36]=[N:20][N:19]=3)[CH:15]=2)[C:10]([C:21]([NH:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[C:27]([F:32])[CH:26]=2)=[O:22])=[C:9]1[CH:33]([CH3:35])[CH3:34])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 31214Ethyl orthoformateHCID 597622831-Benzyl-N-(3,4-difluorobenzyl)-6-(hydrazinecarbonyl)-2-isopropyl-1H-indole-3-carboxamide2 回

生成物 1

HCID 59762338HCID 59762338、化合物

実験手順

1-benzyl-N-(3,4-difluorobenzyl)-6-(hydrazinecarbonyl)-2-isopropyl-1H-indole-3-carboxamide (Compound 88, 21 mg, 0.044 mmol) in triethyl orthoformate (5 ml) was heated to 145° C. for 5 h, then concentrated in vacuo. The residue was purified by chromatography on silica gel (0→55% EtOAc-hexanes) to yield the title compound as a white solid.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by chromatography on silica gel (0→55% EtOAc-hexanes)

出典と根拠

ORDレコード
ord-a8e6ddbc84534c8bb3d8f70f56ea5076
出典データセット
uspto-grants-2013_09
特許番号
US08524917B2

反応ノート

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