5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → HCID 86683373, compound

HRID 400962Notes

Reaction equation

HRID 400962 reaction equation
C(C1N=C(N2CCOCC2)C2N=NN(CC3C=CC=CC=3Cl)C=2N=1)(C)(C)C.[C:28]([C:32]1[N:33]=[C:34](Cl)[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29].[CH2:50]([N:52]([CH:56]1[CH2:60][CH2:59][NH:58][CH2:57]1)[C:53](=[O:55])[CH3:54])[CH3:51]>>[C:28]([C:32]1[N:33]=[C:34]([N:58]2[CH2:59][CH2:60][CH:56]([N:52]([CH2:50][CH3:51])[C:53](=[O:55])[CH3:54])[CH2:57]2)[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29]

Participants

4

Reactant 3

HCID 14339535-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 27562743-(N-Acetyl-N-ethylamino)pyrrolidineHCID 866832845-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Product 1

HCID 86683373HCID 86683373, compound

Procedure

In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chlorobenzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and N-ethyl-N-(pyrrolidin-3-yl)acetamide. MS (m/e): 456.5 (MH+).

Sources & evidence

ORD record
ord-c8563d4cccc94bcc85bc61704225568c
Source dataset
uspto-grants-2014_06
Patent number
US08741906B2

Reaction notes

Loading…