1-Bromo-2-fluorobenzene → 1-(2-Fluorophenyl)-2-phenylethan-1-one

HRID 401158Notes

Reaction equation

HRID 401158 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[F:8].ClC1C=C([C:17](=[O:25])[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)C=C(Cl)C=1>>[F:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:17](=[O:25])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanone

Product 1

HCID 126933791-(2-Fluorophenyl)-2-phenylethan-1-oneYield 33.5%

Procedure

Prepared from 1-bromo-2-fluorobenzene following the procedure described in Intermediate 13, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 24 (300 mg, yield 33.5%).

Workup

  1. customwas purified by column chromatography (PE:EtOAc=100:1)

Sources & evidence

ORD record
ord-f45c17d5f26b450bacad0cf2cfeaffd9
Source dataset
uspto-grants-2014_06
Patent number
US08741915B2

Reaction notes

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