反应详情

温度

160 °C

To a solution of ethyl 3-oxo-3-(pyridin-3-yl)-2-(thiophen-3-yl)propanoate (2 g, 7.26 mmol) in DMSO (20 mL) was added catalytic amount of brine (0.2 mL). The reaction mixture was heated at 160° C. for 2 h. The reaction mixture was cooled to room temperature, diluted with water, and extracted with EtOAc. The organic layer was concentrated in vacuo and purified by column chromatography to afford Intermediate 56 (1 g, yield 68%).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted with EtOAc
3. concentrationThe organic layer was concentrated in vacuo
4. custompurified by column chromatography