Nitric Acid → HCID 18452163, compound

HRID 401189Notes

Reaction equation

HRID 401189 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[N+:11]([O-])([OH:13])=[O:12]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=[O:6]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 170223-Chloro-4-hydroxybenzaldehyde

Product 1

HCID 18452163HCID 18452163, compoundYield 58.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 3-chloro-4-hydroxybenzaldehyde (400 mg, 2.55 mmol) in acetic acid (5 mL) was added concentrated nitric acid (0.1 mL) and at 0° C., the resulting suspension was stirred at 25° C. for 6 h. The mixture was poured into ice water; the solid was collected by filtration, washed with water (30 mL) and dried in vacuo to give Intermediate 59 (300 mg, 58.4%).

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed with water (30 mL)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0b44b3d9b531450e860893c6fbbb38bc
Source dataset
uspto-grants-2014_06
Patent number
US08741915B2

Reaction notes

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