Dimethylformamide → 5-Formyl-2-hydroxybenzonitrile

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-bromo-4-hydroxybenzaldehyde (1.00 g, 4.97 mmol) in DMF (10 mL) was added cuprous cyanide (660 mg, 7.46 mmol). The mixture was heated at 180° C. for 8 hours. The solution was filtered off and purified by chromatography on silica gel (PE/EtOAc=8:1) (210 mg, 29%).

Provenance & Evidence