Diethyl (ethoxymethylene)malonate → 2-[(2-Bromo-5-methoxyphenylamino)methylene]malonic acid diethyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-5-methoxy-phenylamine (540 mg, 2.64 mmol) and diethyl 2-(ethoxymethylene)malonate (600 mg, 2.7 mmol) was stirred at 100° C. for 2 h. After cooling, the reaction mixture was recrystallized from methanol (10 mL) to give 2-[(2-bromo-5-methoxy-phenylamino)-methylene]-malonic acid diethyl ester as a yellow solid (0.8 g, 81%).

Provenance & Evidence