化工社化工社 化学情報印刷レポート · 研究参考用
O-Toluidine → 2,2,2'-Trimethylpropionanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Toluidine | HCID 7242 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Pivaloyl chloride | HCID 62493 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,2,2'-Trimethylpropionanilide | HCID 2734005 | 92% |
反応手順
To a solution of o-tolylamine (21.4 g, 0.20 mol) and Et3N (22.3 g, 0.22 mol) in CH2Cl2 was added 2,2-dimethyl-propionyl chloride (25.3 g, 0.21 mol) at 10° C. The mixture was stirred overnight at room temperature, washed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine, dried over Na2SO4 and concentrated under vacuum to give 2,2-dimethyl-N-o-tolyl-propionamide (35.0 g, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741925B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-a917c539fa5e492682d65117d70ad927 |
| 出典メモ | uspto-grants-2014_06 |