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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40127Generated: October 26, 2026

2-(Chloromethyl)-1,3-oxazole → 1-Benzyl-N-(3,4-difluorobenzyl)-2-isopropyl-6-(1,3-oxazol-2-ylmethoxy)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40127

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-1,3-oxazoleHCID 21957543—
Reactant1-Benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamideHCID 25160740—
Product1-Benzyl-N-(3,4-difluorobenzyl)-2-isopropyl-6-(1,3-oxazol-2-ylmethoxy)-1H-indole-3-carboxamideHCID 59762434—

Reaction Steps

The title compound was prepared from 1-benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamide (Compound 8) and 2-(chloromethyl)oxazole by General Procedure N.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-3c6c12fb233c420bb38139e80515b453
Source noteuspto-grants-2013_09