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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40143Generated: October 25, 2026

Hydrogen Bromide → 6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40143

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen BromideHCID 260—
ReactantBromocyclobutaneHCID 78110—
Reactant3,4-DifluorobenzylamineHCID 123572—
Reactant3-(Bromomethyl)pyridineHCID 245934—
Reactant2-isopropyl-6-methoxy-1H-indole-3-carbaldehydeHCID 59762309—
Product6-Cyclobutoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1-(pyridin-3-ylmethyl)-1H-indole-3-carboxamideHCID 59762358—

Reaction Steps

The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137), 3-(bromomethyl)pyridine.HBr, 3,4-difluorobenzylamine, and cyclobutyl bromide by, in order, General Procedure J, General Procedure K, General Procedure C, General Procedure L, and General Procedure N.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-55f9e6fabcba425ab1c1072f1aee8be9
Source noteuspto-grants-2013_09