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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 401456Generated: October 30, 2026

6-Bromoimidazo[1,2-a]pyridine-3-carbaldehyde → 6-(5-Fluoropyridin-3-yl) imidazo[1,2-a]pyridine-3-carbaldehyde

https://huagongshe.com/reaction/401456

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromoimidazo[1,2-a]pyridine-3-carbaldehydeHCID 21345676—
Reactant(5-Fluoropyridin-3-yl)boronic acidHCID 44717403—
Product6-(5-Fluoropyridin-3-yl) imidazo[1,2-a]pyridine-3-carbaldehydeHCID 8667060452%

Reaction Steps

The title compound was prepared by following the procedure as described for Intermediate 1 using 6-bromoimidazo[1,2-a]pyridine-3-carbaldehyde and 5-fluoropyridin-3-ylboronic acid. Yield: 52%; 1H NMR (DMSO-d6; 300 MHz): δ 10.01 (s, 1H), 9.66 (s, 1H), 8.84 (s, 1H), 8.66-8.67 (d, 1H, J=2.1 Hz), 8.59 (s, 1H), 8.18-8.21 (d, 1H, J=9 Hz), 8.08-8.11 (d, 1H, J=9.6 Hz), 8.03 (s, 1H); MS: m/z 241.6 (M+1)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08741932B2
Source datasetuspto-grants-2014_06
ORD IDord-1d7b034eeca742a7b101375cc0ab8683
Source noteuspto-grants-2014_06