Trifluoroacetic acid → (2-Aminopyridin-3-yl)(3-(piperazin-1-yl)isoquinolin-1-yl)methanone bis(2,2,2-trifluoroacetate)

Participants

Reaction Steps

To a solution of tert-butyl 4-(1-(2-aminonicotinoyl)isoquinolin-3-yl)piperazine-1-carboxylate (6 mg, 0.014 mmol) in dichloromethane (2 ml) was added trifluoroacetic acid (0.5 ml). The solution was stirred at room temperature for 1 hour. The resulting mixture was concentrated in vacuo and triturated twice with ether and dried to leave the compound as an orange solid (2 mg, 26% yield).

Provenance & Evidence