HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → N-(3,4-Difluorobenzyl)-2-isopropyl-6-(1H-pyrazol-5-yl)-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 3-(3,4-Difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate | HCID 86621607 | — |
| Reactant | HCID 178514837 | HCID 178514837 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | N-(3,4-Difluorobenzyl)-2-isopropyl-6-(1H-pyrazol-5-yl)-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide | HCID 59762428 | — |
Reaction Steps
Following General Procedure BB, 3-(3,4-difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate (Compound 202, 29 mg, 0.05 mmol), was reacted with 1H-pyrazole boronic acid (9 mg, 0.08 mmol), LiCl (7 mg, 0.18 mmol), Na2CO3 (aqueous) (2M, 0.1 ml), Pd(PPh3)4 (3 mg, 0.003 mmol) to yield the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524917B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-ac3289c6aea3481ebf4e4282a141a81f |
| Source note | uspto-grants-2013_09 |