HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → N-(3,4-Difluorobenzyl)-2-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | (1-methyl-1H-pyrazol-5-yl)boronic acid | HCID 11182610 | — |
| Reactant | 3-(3,4-Difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate | HCID 86621607 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | N-(3,4-Difluorobenzyl)-2-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide | HCID 59762320 | — |
Reaction Steps
Following General Procedure BB, 3-(3,4-difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate (Compound 202, 39 mg, 0.07 mmol), was reacted with 1-methyl-1H-pyrazole-5-boronic acid pinocol ester (21 mg, 0.09 mmol), LiCl (9 mg, 0.18 mmol), Na2CO3 (aqueous) (2M, 0.1 ml), Pd(PPh3)4 (4 mg, 0.003 mmol) to yield the title compound as a white solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524917B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-2aa44d43c1a345fb9dcc876aafb80477 |
| Source note | uspto-grants-2013_09 |