Bromine → 2-Bromo-2'-chloroacetophenone

HRID 401588Notes

Reaction equation

HRID 401588 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

Product 1

HCID 27357852-Bromo-2'-chloroacetophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (3.8 mL, 65 mmol) was added dropwise to a solution of 1-(2-chloro-phenyl)-ethanone (10. g, 65 mmol) in acetic acid (75 mL) at 0° C. The mixture was then warmed to room temperature and stirred overnight. The mixture was evaporated to dryness and used in the next step without further purification.

Workup

  1. customThe mixture was evaporated to dryness
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-06ee169886c148349fb07f4964961e04
Source dataset
uspto-grants-2014_06
Patent number
US08741939B2

Reaction notes

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