HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxo-azetidine-1-carboxylic acid tert-butyl ester → 3-[4-(Thiazole-2-carbonyl)-piperazin-1-yl]-azetidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxo-azetidine-1-carboxylic acid tert-butyl ester | HCID 1519404 | — |
| Reactant | Piperazin-1-yl(thiazol-2-yl)methanone | HCID 21641598 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[4-(Thiazole-2-carbonyl)-piperazin-1-yl]-azetidine-1-carboxylic acid tert-butyl ester | HCID 59626013 | — |
Reaction Steps
A solution of compound 7b (6.1 g, 0.031 mol) and (5.1 g, 0.03 mol) compound 4a in MeOH (30 mL) was stirred for 15 min. Decaborane (1 g, 0.008 mol) was added and the reaction was stirred for 18 h. The solvent was evaporated in vacuo. The residue was used without further purification for the next step. MS m/z (M+H+) 353.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741887B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-21ee5813b94e4a07bde01b7d81060769 |
| Source note | uspto-grants-2014_06 |