HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 401631Generated: October 27, 2026
2-(Tributylstannyl)-1,3-thiazole → HCID 59626021, compound
https://huagongshe.com/reaction/401631
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Tributylstannyl)-1,3-thiazole | HCID 2763259 | — |
| Reactant | Ethyl 2-bromo-6-benzothiazolecarboxylate | HCID 12067225 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59626021 | HCID 59626021 | 84.5% |
Reaction Steps
A mixture of ethyl 2-bromo-benzothiazole-6-carboxylate 1w (150 mg, 0.53 mmol), 2-tributylstannylthiazole 9p (0.25 mL, 0.79 mmol), and Pd(PPh3)4 (30 mg, 0.03 mmol) in dioxane (2 mL) was heated at 130° C. for 30 min under microwave. The reaction mixture was diluted with CH2Cl2, washed with aq. NaHCO3, dried over Na2SO4, and concentrated. Purification by flash column chromatography (silica gel, 10% EtOAc/heptane) gave 9q (130 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08741887B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-f4ff35d68563447f93e07cbcb4e7905f |
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| Source note | uspto-grants-2014_06 |
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