3-(Bromomethyl)-5-methylisoxazole → 2-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carbaldehyde

HRID 40165Notes

Reaction equation

HRID 40165 reaction equation
[CH:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2].Br[CH2:18][C:19]1[CH:23]=[C:22]([CH3:24])[O:21][N:20]=1>>[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[CH:23]=[C:22]([CH3:24])[O:21][N:20]=2)[C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27763043-(Bromomethyl)-5-methylisoxazoleHCID 597623092-isopropyl-6-methoxy-1H-indole-3-carbaldehyde2×

Product 1

HCID 866216082-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carbaldehyde

Procedure

The title compound was prepared from 2-isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137) and 3-(bromomethyl)-5-methylisoxazole by General Procedure J.

Sources & evidence

ORD record
ord-d85cc53b90e44e3bb0e90dbb21ff1e9b
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Reaction notes

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