N-(3,4-Difluorobenzyl)-6-isopropoxy-2-isopropyl-1-(oxazol-2-ylmethyl)-1H-indole-3-carboxamide → 2-Isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carboxylic Acid
Reaction equation
[CH:1]([C:4]1[N:5]([CH2:17][C:18]2[CH:22]=[C:21]([CH3:23])[O:20][N:19]=2)[C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2].FC1C=C(C=CC=1F)CNC(C1C2C(=CC(OC(C)C)=CC=2)N(CC2OC=CN=2)C=1C(C)C)=[O:31]>>[CH:1]([C:4]1[N:5]([CH2:17][C:18]2[CH:22]=[C:21]([CH3:23])[O:20][N:19]=2)[C:6]2[C:11]([C:12]=1[C:13]([OH:31])=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from 2-isopropyl-6-methoxy-1-((5-methylisoxazol-3-yl)methyl)-1H-indole-3-carbaldehyde (Compound 213) by General Procedure K.
Sources & evidence
- ORD record
- ord-7d95345af84f4e64950459918d1e4cec
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524917B2
Reaction notes
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