Lithium hydroxide, monohydrate → 3-(4-fluorophenyl)-1H-indole-6-carboxylic acid

Participants

Reaction Steps

A solution of compound 53d (303 mg, 0.79 mmol), and LiOH.H2O (132.7 mg, 3.16 mmol) in THF/H2O (10 mL/10 mL) was stirred at 45° C. for 5 h. The resulting mixture was concentrated and diluted with water. The water layer was acidified with 1N aqueous HCl to pH˜4 and extracted with CH2Cl2. The organic solution was dried over Na2SO4 and concentrated to give 53e (249 mg), which was used in the next reaction without further purification. MS m/z (M+H+) 256.0.

Provenance & Evidence