HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(trifluoromethyl)benzylamine → N-[3-fluoro-4-(trifluoromethyl)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(trifluoromethyl)benzylamine | HCID 2737567 | — |
| Reactant | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid | HCID 57732214 | — |
| Product | N-[3-fluoro-4-(trifluoromethyl)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide | HCID 57732202 | — |
Reaction Steps
The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 3-fluoro-4-(trifluoromethyl)benzylamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741934B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-07057a4a540c421d95d7e96485eb3b84 |
| Source note | uspto-grants-2014_06 |