4-(Trifluoromethyl)benzylamine → 4-{[(5-Chloro-1,3-thiazol-2-yl)amino]sulfonyl}-2-cyano-N-[4-(trifluoromethyl)benzyl]benzamide

HRID 401737Notes

Reaction equation

HRID 401737 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][NH2:8])=[CH:5][CH:4]=1.[Cl:13][C:14]1[S:18][C:17]([NH:19][S:20]([C:23]2[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[C:25]([C:32]#[N:33])[CH:24]=2)(=[O:22])=[O:21])=[N:16][CH:15]=1>>[Cl:13][C:14]1[S:18][C:17]([NH:19][S:20]([C:23]2[CH:31]=[CH:30][C:26]([C:27]([NH:8][CH2:7][C:6]3[CH:9]=[CH:10][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:4][CH:5]=3)=[O:28])=[C:25]([C:32]#[N:33])[CH:24]=2)(=[O:22])=[O:21])=[N:16][CH:15]=1

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 866307814-{[(5-Chloro-1,3-thiazol-2-yl)amino]sulfonyl}-2-cyanobenzoic acid

Product 1

HCID 577319894-{[(5-Chloro-1,3-thiazol-2-yl)amino]sulfonyl}-2-cyano-N-[4-(trifluoromethyl)benzyl]benzamide

Procedure

The title compound was prepared from 4-(trifluoromethyl)benzylamine and 4-{[(5-chloro-1,3-thiazol-2-yl)amino]sulfonyl}-2-cyanobenzoic acid of Preparation 22, following Method O described for Example 344. The reaction mixture was stirred at room temperature for 18 hours.

Sources & evidence

ORD record
ord-87f33ec58f2b4877b60d133d6e10f0f3
Source dataset
uspto-grants-2014_06
Patent number
US08741934B2

Reaction notes

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