反应详情

A mixture of 4-amino-2-fluorobenzonitrile (25 g, 0.183 mmol) and potassium hydroxide (125 g, 2.23 mol) in water (350 ml) and industrial methylated spirit (50 ml) was heated at reflux for 48 hours. The solvent was evaporated in vacuo and the residue diluted with water and washed with DCM. The aqueous phase was acidified to pH 5.5 with concentrated HCl and the resultant precipitate collected by filtration to yield the title compound as a beige solid (23.94 g, 0.154 mol 84%).

1. temperaturewas heated
2. temperatureat reflux for 48 hours
3. customThe solvent was evaporated in vacuo
4. additionthe residue diluted with water
5. washwashed with DCM
6. filtrationthe resultant precipitate collected by filtration