HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-([[3-Chloro-4-(trifluoromethyl)benzyl]amino]carbonyl)benzenesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-4-(trifluoromethyl)benzylamine | HCID 23512744 | — |
| Reactant | Potassium 4-carboxybenzenesulfonate | HCID 23670833 | — |
| Product | 4-([[3-Chloro-4-(trifluoromethyl)benzyl]amino]carbonyl)benzenesulfonyl chloride | HCID 57731928 | 45% |
Reaction Steps
The title compound was prepared from 4-sulphobenzoic acid monopotassium salt and 3-chloro-4-(trifluoromethyl)benzylamine in 45% yield following the procedure described in Preparation 1. The thionyl chloride solution was heated at reflux for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741934B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-744406d3034340fcb6671c74fe7e611b |
| Source note | uspto-grants-2014_06 |