HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2S)-2-[(3-Chlorophenoxy)methyl]pyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (2S)-2-[(3-chlorophenoxy)methyl]pyrrolidine-1-carboxylate | HCID 57732115 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2S)-2-[(3-Chlorophenoxy)methyl]pyrrolidine hydrochloride | HCID 68534217 | — |
Reaction Steps
tert-Butyl (2S)-2-[(3-chlorophenoxy)methyl]pyrrolidine-1-carboxylate (Preparation 89, 1.50 g, 4.81 mmol) was stirred with 4 M of hydrogen chloride in 1,4-dioxane (10 mL). After 2 h, the reaction mixture was concentrated in vacuo (TLC analysis showed only baseline material in 3:1 hexanes-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741934B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-172ce94496f046a6a709ed6019fa0b66 |
| Source note | uspto-grants-2014_06 |