反应详情

温度

90 °C

A mixture of 4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline-7-carbonitrile (0.300 g, 0.793 mmol) and SULFURIC ACID (3.00 ml, 56.3 mmol) was heated at 90° C. for 30 min. Quenched onto ice and sodium bicarbonate. Isolated solid by filtration and purified on RPHPLC. Fractions containing product were treated with 9% sodium carbonate. Removed volatiles. Product crashed out and was isolated by filtraton. MS m/z=397.1 [M+1]+. Calc'd for C22H16N6O2: 396.4.

1. customQuenched onto ice and sodium bicarbonate
2. customIsolated solid
3. filtrationby filtration
4. custompurified on RPHPLC
5. additionFractions containing product
6. additionwere treated with 9% sodium carbonate
7. customwas isolated by filtraton