反应详情

To a solution of 5-(3-((7-methoxyquinolin-4-yloxy)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-3-methylthiophene-2-carbonyl chloride (0.100 g, 0.21 mmol) in dichloromethane (2 mL) at 0° C. was added morpholine (0.19 g, 2.1 mmol). The solution was stirred at room temperature twenty minutes, then was concentrated and purified by MPLC chromatography (eluted with 3% methanol in dichloromethane) to yield a yellow solid. Trituration in acetonitrile and filtration afforded the product as a white solid. MS m/z=517.2 [M+1]+. Calc'd for C26H24N6O4S: 516.2.

1. concentrationwas concentrated
2. custompurified by MPLC chromatography (eluted with 3% methanol in dichloromethane)
3. customto yield a yellow solid
4. filtrationTrituration in acetonitrile and filtration