(+/-)-cis-4-Azidomethyl-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester → tert-butyl (3S,4R)-4-(aminomethyl)-3-fluoropiperidine-1-carboxylate

Participants

Reaction Steps

To a stirred solution of (±)-cis-4-azidomethyl-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester (0.68 mmol, 160 mg) in methanol (1.5 mL) was added Pd—C (20% by wt., 35 mg). The reaction was hydrogenated under balloon pressure for 2 h at room temperature. The reaction was filtered through a bed of celite. The solvent was evaporated to provide (±)-cis-4-aminomethyl-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence