HCID 86657843, compound → tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

HRID 402090Notes

Reaction equation

HRID 402090 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH:10]([N:16]=[N+]=[N-])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:14])([F:15])[CH:10]([NH2:16])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86657843HCID 86657843, compound

Product 1

HCID 67373260tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-azido-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester (0.68 mmol, 0.18 g) in MeOH (4.0 mL), was added Pd—C (10% by wt, 30 mg) and stirred under H2 atmosphere (balloon) for 3 h. The catalyst was filtered and washed with DCM, and the filtrate was concentrated under reduced pressure to provide 3-amino-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester.

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with DCM
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-89c999a14501417aac9ff0f6cd981096
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

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