Carbon Tetrachloride → HCID 59791338, compound

Participants

Reaction Steps

To tert-butyl 2-{2-[4-(2-hydroxyethyl)phenoxy]-ethoxy}ethylcarbamate (0.56 g, 1.7 mmol) dissolved in 10 ml carbon tetrachloride was added triphenylphosphine bound on styrene (861 mg, 2.6 mmol of about 3 mmol/g resin). The reaction mixture was heated to reflux for 2 hours. After the required time the reaction was cooled and filtered. After drying a quantitative yield of product was isolated. 1H NMR (CDCl3) δ 7.11 (d, 2H, Ar), 6.86 (d, 2H, Ar), 4.95 (bs, exchangeable, NH), 4.08 (dd, CH2—O), 3.79 (dd, CH2—O), 3.65 (t, CH2—Cl), 3.59 (t, CH2—O), 3.32 (bm, CH2—NH), 2.99 (t, CH2—Ar), 1.70 (bs, exchangeable, OH) 1.42 (s, 9H, CH3). Mass spectrum, m/e Calcd for C17H27ClNO4+: 344.16 (100%), 346.16 (32%). Found: 344.57, 346.55.

Provenance & Evidence