HCID 135453913, compound → HCID 135692740, compound

HRID 402321Notes

Reaction equation

HRID 402321 reaction equation
[C@@H:1]1([N:10]2[C:14]3[N:15]=[N:16][NH:17][C:18](=[O:19])[C:13]=3[N:12]=[CH:11]2)[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@H:2]1[OH:3]>N1C=CC=CC=1.O>[C:2]([O:3][C@@H:2]1[C@H:4]([O:5][C:4](=[O:5])[CH3:6])[C@@H:6]([CH2:8][O:9][C:18](=[O:19])[CH3:13])[O:7][C@H:1]1[N:10]1[C:14]2[N:15]=[N:16][NH:17][C:18](=[O:19])[C:13]=2[N:12]=[CH:11]1)(=[O:3])[CH3:1]

Participants

4

Reactant 1

HCID 135453913HCID 135453913, compound

Product 1

HCID 135692740HCID 135692740, compoundYield 121.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Conditions

Temperature
20 °C

Procedure

The compound from Step A (1.68 gr, 6.24 mmol) was stirred in pyridine (20 mL). The anhydride acetic (2.3 ml, 25 mmol) was added and the mixture was stirred at 20° C. for 16 hours. The mixture was evaporated to dryness to give a syrup which was dissolved in water. The aqueous layer was extracted by acetyl acetate. The organic layer was evaporated to dryness to give the title compound (1.5 gr) as a brown foam.

Workup

  1. customThe mixture was evaporated to dryness
  2. customto give a syrup which
  3. extractionThe aqueous layer was extracted by acetyl acetate
  4. customThe organic layer was evaporated to dryness

Sources & evidence

ORD record
ord-9acd7c6bf5bd4770b651cf46eee82094
Source dataset
uspto-grants-2014_06
Patent number
US08742101B2

Reaction notes

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