Dimethylformamide → 2-[3-(Methylthio)pyridin-4-yl]-5-(trifluoromethyl)benzothiazole

Participants

Reaction Steps

A mixture of 0.30 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzothiazole, 0.14 g of methylmercaptan sodium salt and 3 ml of DMF was stirred at room temperature for 20 minutes. To the reaction mixture was added water, and the resultant mixture was extracted with ethyl acetate three times. The combined organic layers were washed with water and saturated saline, dried over magnesium sulfate, then, concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, to obtain 2-[3-(methylthio)pyridin-4-yl]-5-(trifluoromethyl)benzothiazole (hereinafter, referred to as the present compound 5).

Provenance & Evidence