反应详情

A mixture of 0.90 g of 2-(3-fluoropyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine, 0.32 g of ethylmercaptan sodium salt and 12 ml of DMF was stirred for 1 hour under ice cool. To the reaction mixture was added water, and the deposited solid was collected by filtration. This solid was washed with water, then, dissolved in ethyl acetate. The organic layer was washed with saturated saline, dried over magnesium sulfate, then, concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, to obtain 0.89 g of 2-[3-(ethylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine (hereinafter, referred to as the present compound 15).

1. temperaturecool
2. filtrationthe deposited solid was collected by filtration
3. washThis solid was washed with water
4. dissolutiondissolved in ethyl acetate
5. washThe organic layer was washed with saturated saline
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under reduced pressure