Diisopropylethylamine → HCID 57334039, compound

Participants

Reaction Steps

To a solution of 6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid (155 mg, 0.50 mmol) and TBTU (177 mg, 0.55 mmol) in DMF (2.5 mL) was added DIPEA (428 μL, 2.50 mmol). Then 4-aminotetrahydropyran (56 mg, 0.55 mmol) was added and the mixture was stirred at room temperature under Ar for 1 h. The mixture was then evaporated and purification by chromatography (silica, 0 to 100% ethyl acetate in heptane, then 5% methanol in dichloromethane) afforded the title compound (43 mg, 22%) as a white solid after recrystallisation from ethyl acetate/heptane. MS: m/e=394.1 [M+H]+.

Provenance & Evidence