N-Aminomorpholine → HCID 57334040, compound

HRID 402347Notes

Reaction equation

[CH3:1][N:2]1[C:6]([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][N:10]=2)=[C:5]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:4]=[N:3]1.[NH2:24][N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[CH3:1][N:2]1[C:6]([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([NH:24][N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[O:15])=[CH:11][N:10]=2)=[C:5]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:4]=[N:3]1

Participants

Reactant 2

HCID 20315N-Aminomorpholine

HCID 67499016HCID 67499016, compound

Product 1

HCID 57334040HCID 57334040, compoundYield 84%

Procedure

As described for example 2b, 6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid (155 mg, 0.5 mmol) was converted, using N-aminomorpholine instead of 4-aminotetrahydropyran, to the title compound (165 mg, 84%) which was obtained as a white solid. MS: m/e=395.2 [M+H]+.

Sources & evidence

ORD record: ord-22a299965c014423872f296f9a4091b7
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08742097B2

Reaction notes

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