Ethanamine, 2,2,2-trifluoro- → HCID 57334197, compound

HRID 402350Notes

Reaction equation

HRID 402350 reaction equation
[CH3:1][N:2]1[C:6]([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][N:10]=2)=[C:5]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:4]=[N:3]1.[F:24][C:25]([F:29])([F:28])[CH2:26][NH2:27]>>[CH3:1][N:2]1[C:6]([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([NH:27][CH2:26][C:25]([F:29])([F:28])[F:24])=[O:15])=[CH:11][N:10]=2)=[C:5]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:4]=[N:3]1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 67499016HCID 67499016, compound

Product 1

HCID 57334197HCID 57334197, compoundYield 58%

Procedure

As described for example 2b, 6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid (155 mg, 0.5 mmol) was converted, using 2,2,2-trifluoroethylamine instead of 4-aminotetrahydropyran, to the title compound (127 mg, 58%) which was obtained as a white solid after a further recrystallisation from ethyl acetate. MS: m/e=392.1 [M+H]+.

Sources & evidence

ORD record
ord-24c8b282626b4ee083881fdcf09f2d12
Source dataset
uspto-grants-2014_06
Patent number
US08742097B2

Reaction notes

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